England one-day captain Eoin Morgan and opening batsman Alex Hales have opted out of October's tour of Bangladesh because of security concerns.
No international side has toured Bangladesh since 20 people were killed in a siege at a cafe in Dhaka in July.
The ECB said in August that the three one-day internationals and two Tests would go ahead after a security review.
Jos Buttler will captain the one-day side, with the one-day and Test squads to be named on Friday.
'We respect their decision'
England director of cricket Andrew Strauss said: "Whilst we understand and respect Eoin and Alex's decision, we are disappointed that they have made themselves unavailable for selection for the Bangladesh tour."
He added that after "open and honest" discussions with all the players, no further withdrawals are expected.
Former England captain Michael Vaughan has described Morgan's decision as a "huge mistake", while Nasser Hussain, another ex-skipper, said Morgan "should be with his team".
Stuart Broad, Moeen Ali, Chris Jordan and Liam Dawson have publicly said they will tour.
Last week, Strauss told BBC Test Match Special that anyone who does not travel is giving a chance to another player.
England fly out on 29 September, with the one-day series starting on 7 October and the Test series on 20 October.
They follow that with a tour of India made up of five Tests, three ODIs and three Twenty20s.
England in Bangladesh - tour schedule
What has Morgan said?
Morgan, 29, said this week that he would never go on a tour where security concerns may affect his game.
"In 2010 we played an Indian Premier League game in Bangalore and a bomb went off in the ground. Immediately we left and went straight to the airport," he said.
"Another one was playing domestic cricket in Bangladesh during political elections and things were incredibly violent.
"Given that no-one has toured there since the terrorist attack adds a bigger decision to it."
Analysis: What does this mean for Morgan & Hales' futures?
BBC Sport cricket correspondent Jonathan Agnew:
"Morgan has never expressed any positive views on making this tour, so his decision to pull out is not a surprise.
"In his explanation, Morgan refers to a bomb blast in Bangalore in 2010, an incident that profoundly unsettled him, as did civil unrest in Bangladesh.
"It won't be lost on Strauss, though, that Morgan has returned to play in both countries since.
"However, having guaranteed that players' futures will not be affected by this decision, it's difficult to see Morgan losing the captaincy, as has been suggested in some quarters.
"Hales has effectively given another opening batsman the chance to take his place in Test cricket, although his future in that form was doubtful anyway.
"After a record-breaking summer, he's sure to return to the one-day team in India."
England one-day captain Eoin Morgan and opening batsman Alex Hales have opted out of October's tour of Bangladesh because of security concerns.
No international side has toured Bangladesh since 20 people were killed in a siege at a cafe in Dhaka in July.
The ECB said in August that the three one-day internationals and two Tests would go ahead after a security review.
Jos Buttler will captain the one-day side, with the one-day and Test squads to be named on Friday.
'We respect their decision'
England director of cricket Andrew Strauss said: "Whilst we understand and respect Eoin and Alex's decision, we are disappointed that they have made themselves unavailable for selection for the Bangladesh tour."
He added that after "open and honest" discussions with all the players, no further withdrawals are expected.
Former England captain Michael Vaughan has described Morgan's decision as a "huge mistake", while Nasser Hussain, another ex-skipper, said Morgan "should be with his team".
Stuart Broad, Moeen Ali, Chris Jordan and Liam Dawson have publicly said they will tour.
Last week, Strauss told BBC Test Match Special that anyone who does not travel is giving a chance to another player.
England fly out on 29 September, with the one-day series starting on 7 October and the Test series on 20 October.
They follow that with a tour of India made up of five Tests, three ODIs and three Twenty20s.
England in Bangladesh - tour schedule
What has Morgan said?
Morgan, 29, said this week that he would never go on a tour where security concerns may affect his game.
"In 2010 we played an Indian Premier League game in Bangalore and a bomb went off in the ground. Immediately we left and went straight to the airport," he said.
"Another one was playing domestic cricket in Bangladesh during political elections and things were incredibly violent.
"Given that no-one has toured there since the terrorist attack adds a bigger decision to it."
Analysis: What does this mean for Morgan & Hales' futures?
BBC Sport cricket correspondent Jonathan Agnew:
"Morgan has never expressed any positive views on making this tour, so his decision to pull out is not a surprise.
"In his explanation, Morgan refers to a bomb blast in Bangalore in 2010, an incident that profoundly unsettled him, as did civil unrest in Bangladesh.
"It won't be lost on Strauss, though, that Morgan has returned to play in both countries since.
"However, having guaranteed that players' futures will not be affected by this decision, it's difficult to see Morgan losing the captaincy, as has been suggested in some quarters.
"Hales has effectively given another opening batsman the chance to take his place in Test cricket, although his future in that form was doubtful anyway.
"After a record-breaking summer, he's sure to return to the one-day team in India."
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